Prof. W. K. Liu - Northwestern University USA

IMMERSED MOLECULAR ELECTROKINETIC FINITE ELEMENT METHOD FOR NANO-DEVICES IN BIOTECHNOLOGY AND DRUG DELIVER

Wing Kam Liu, Walter P. Murphy Professor, Northwestern University

Founding Chair of the ASME Nanotechnology Council

World Class Professor at SKKU

http://www.tam.northwestern.edu/wkl/liu.html, w-liu@northwestern.edu

The lecture opens with a discussion on modern uses of multiscale analysis, uncertainty quantification techniques, and validation experiments for the design of nanodevices in biotechnology and medicine. The 3D immersed molecular electrokinetic finite element method (IMEFEM) will be presented for the modeling of micro fluidic electrokinetic assembly of nano wires and filaments and bio-molecules. This transformative bio-nanotechnology is being developed to enable drug delivery systems to achieve desired therapeutic effects and for the design and optimization of an electric field enabled nanotip DNA sensor. For the Nanodiamond-based drug delivery device we will discuss the multiscale analysis, quantum and molecular mechanics, immersed finite element and meshfree methods, uncertainty quantification, validation experiments. In addition, we will describe the mathematical formulation of pH control interactions among chemically functionalized nanodiamond, doxorubicin hydrochloride drugs and biocompatible parylene polymer. For the nanotip, we will discuss the underlying mechanics and physical parameters influencing the bio-sensing efficiency of the nanotip, such as the threshold of applied electric field, nano/microfluidics, bio-molecule deformation, and nanoscale Brownian motion. Through multiscale analysis, we will provide guidelines for nanodevice design, including fundamental mechanisms driving the system performance and optimization of distinct parameters for the high-sensitivity device throughput.

Prof. D. Qian - University of Cincinnati USA

HIGH CYCLE FATIGUE SIMULATION USING EXTENDED SPACE-TIME FINITE ELEMENT METHOD COUPLED WITH CONTINUUM DAMAGE MECHANICS

 Dong Qian

Mechanical Engineering Program

School of Dynamic Systems

University of Cincinnati, Cincinnati, OH 45221-0072

Website: http://altmine.mie.uc.edu/dqian/, Email: dong.qian@uc.edu

A multiple temporal scale computational approach for assessing the fatigue life of engineering materials and components is presented in this talk. This full-scale simulation approach is proposed in light of the challenges in employing the traditional computational method based on Finite Element Method (FEM)) and semi-discrete schemes for fatigue design and analysis. Simulating loading conditions with cycles on the order of hundreds of thousands and beyond is generally an impractical task for FEM even with the high-performance computing platform. This talk will focus on the two critical aspects, i.e., the multiple time scales associated with the fatigue loading condition and the fatigue initiation/growth representations. Detailed implementation of integrating a multiscale space-time representation with a robust material model for the fatigue failure will be outlined and demonstrated in the context of a common choice of metal that are used by industry.

Prof. Wing Kam Liu and Prof. Dong Qian at International University - Vietnam National University HCMC